Crusty foods may worsen heart problems associated with diabetes

ScienceDaily (Oct. 22, 2012) — A University of Illinois study suggests avoiding cooking methods that produce the kind of crusty bits you'd find on a grilled hamburger, especially if you have diabetes and know you're at increased risk for cardiovascular disease because of your diagnosis.

"We see evidence that cooking methods that create a crust -- think the edge of a brownie or the crispy borders of meats prepared at very high temperatures -- produce advanced glycation end products (AGEs). And AGEs are associated with plaque formation, the kind we see in cardiovascular disease," said Karen Chapman-Novakofski, a U of I professor of nutrition.

For years nutrition experts have advised people with diabetes to bake, broil, or grill their food instead of frying it, she said.

"That's still true, but if you have diabetes, you should know that AGEs -- byproducts of food preparation methods that feature very high, intense, dry heat -- tend to end up on other tissues in the body, causing long-term damage," she added.

If you're fighting this vascular buildup anyway, Chapman-Novakofski thinks that consuming products containing AGEs could worsen the cardiovascular complications of diabetes.

In the U of I study, the scientists compared the 10-day food intake of 65 study participants in two ethnic groups: Mexicans (who have higher rates of diabetes and a greater risk of complications from the disease) and non-Hispanic whites.

"We found that people with higher rates of cardiovascular complications ate more of these glycated products. For each unit increase in AGEs intake, a study participant was 3.7 times more likely to have moderate to high risk for cardiovascular disease," said Claudia Luevano-Contreras, first author of the study.

The study showed that non-Hispanic whites had a higher intake of AGEs, and they consumed more saturated fats. However, the association between AGEs and cardiovascular disease was stronger than for saturated fats and heart disease, she said.

Eating less saturated fat and more fruits, vegetables, and fiber are important for people with diabetes, but this study shows that food preparation may be important too, she added.

"AGEs are higher in any kind of meat, but especially in ground meat," she said. "If you put hamburgers or brats on the grill, you'll likely have a higher AGEs content than if you chose a whole cut of meat, say round steak or chicken," said Chapman-Novakofski.

Boiling or stewing meat would reduce your AGEs intake further. And scrambling an egg with cooking spray instead of frying it leads to a significant reduction in AGEs, she added.

The scientists said more research is needed before definite recommendations can be made. They are planning another study in which they'll examine past AGEs intake of diabetes patients.

"These findings are preliminary, but they give us ample reason to further explore the association between AGEs and cardiovascular risk among people with diabetes," Chapman-Novakofski noted.

The study is available online in the International Journal of Food Science and Nutrition. Co-authors are Claudia Luevano-Contreras of the University of Illinois and Eugenia Garay-Sevilla and Monica Preciado-Puga of the University of Guanajuato, Mexico. Partial funding was provided by the National Council for Science and Technology of Mexico (CONACYT).

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The above story is reprinted from materials provided by University of Illinois College of Agricultural, Consumer and Environmental Sciences. The original article was written by Phyllis Picklesimer.

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Journal Reference:

Claudia Luevano-Contreras, MA. Eugenia Garay-Sevilla, Monica Preciado-Puga, Karen Marie Chapman-Novakofski. The relationship between dietary advanced glycation end products and indicators of diabetes severity in Mexicans and non-Hispanic whites: a pilot study. International Journal of Food Sciences and Nutrition, 2012; 120710073547001 DOI: 10.3109/09637486.2012.704905

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American Academy of Pediatrics weighs in for first time on organic foods for children

ScienceDaily (Oct. 22, 2012) — Parents know it's important for children to eat a wide variety of fruits and vegetables, low-fat dairy products, and whole grains. But it's less clear whether spending the extra money on organic foods will bring a significant benefit to their children's health.

To offer guidance to parents -- and the pediatricians caring for their children's health -- the American Academy of Pediatrics (AAP) has conducted an extensive analysis of scientific evidence surrounding organic produce, dairy products and meat. The conclusion is mixed: While organic foods have the same vitamins, minerals, antioxidants, proteins, lipids and other nutrients as conventional foods, they also have lower pesticide levels, which may be significant for children. Organically raised animals are also less likely to be contaminated with drug-resistant bacteria because organic farming rules prohibit the non-therapeutic use of antibiotics.

However, in the long term, there is currently no direct evidence that consuming an organic diet leads to improved health or lower risk of disease. No large studies in humans have been performed that specifically address this issue.

"What's most important is that children eat a healthy diet rich in fruits, vegetables, whole grains, and low-fat or fat-free dairy products, whether those are conventional or organic foods. This type of diet has proven health benefits," said Janet Silverstein, MD, FAAP, a member of the AAP Committee on Nutrition and one of the lead authors of the report. "Many families have a limited food budget, and we do not want families to choose to consume smaller amounts of more expensive organic foods and thus reduce their overall intake of healthy foods like produce."

The AAP report, "Organic Foods: Health and Environmental Advantages and Disadvantages," was released on Oct. 22 at the AAP National Conference & Exhibition in New Orleans. It will be published in the November 2012 issue of Pediatrics (published online Oct. 22). The report outlines the research that has been conducted on organic foods, including convincing evidence of lower exposure to pesticides and less contamination of livestock with drug-resistant bacteria.

"At this point, we simply do not have the scientific evidence to know whether the difference in pesticide levels will impact a person's health over a lifetime, though we do know that children -- especially young children whose brains are developing -- are uniquely vulnerable to chemical exposures," said Joel Forman, MD, FAAP, a member of the AAP Council on Environmental Health and one of the lead authors of the AAP clinical report.

If cost is a factor, families can be selective in choosing organic foods, Dr. Forman said. Some conventionally grown fruits and vegetables tend to have lower pesticide residues. The AAP cites organic shopper's guides like those provided by Consumer Reports and the Environmental Working Group as references for consumers. The AAP found no individual health benefit from purchasing organic milk, but emphasizes that all milk should be pasteurized to reduce the risk of bacterial infections. Raw milk increases the risk of serious infection with bacteria including Salmonella, E. coli, Listeria, Campylobacter and Brucella.

Purchasing meat from organic farms that do not use antibiotics for nontherapeutic uses has the potential to reduce antibiotic resistance in bacteria that infect people. The AAP calls for large, well-designed, prospective cohort studies that directly measure environmental exposures such as estrogen at low levels to understand the impact of hormonal exposure of children through milk and meat.

The AAP report also notes that the motivation to choose organic produce, meat and dairy products may be reasonably based on larger environmental issues, as well as human health impacts like pollution and global climate change.

"Pediatricians want families to have the information they need to make wise food choices," said Dr. Forman. "We hope that additional research will improve our understanding of these issues, including large studies that measure environmental exposures and neurodevelopment."

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The above story is reprinted from materials provided by American Academy of Pediatrics, via EurekAlert!, a service of AAAS.

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Journal Reference:

Joel Forman, Janet Silverstein, Committee On Nutrition and Council On Environmental Health. Organic Foods: Health and Environmental Advantages and Disadvantages. Pediatrics, 2012 DOI: 10.1542/peds.2012-2579

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Plant-based foods may offer reduced risk for aggressive prostate cancer

ScienceDaily (Oct. 19, 2012) — President George W. Bush made no secret that he detested broccoli. With all due respect to our former leader, researchers have found one more great reason to add fruits, vegetables, herbs and tea to your diet.

A study by Susan Steck of the Arnold School of Public Health finds that a high intake of flavonoids, a group of compounds found in plants, may lower the risk for highly aggressive prostate cancer.

"Incorporating more plant-based foods and beverages, such as fruits, vegetables, herbs and tea, into the diet may offer some protection against aggressive prostate cancer," said Steck, an associate professor at the Arnold School and an affiliated scholar with the Center for Research in Health Disparities.

"Filling your plate with flavonoid-rich foods is one behavior that can be changed to have a beneficial impact on health," she said.

Steck presented her findings at the International Conference on Frontiers in Cancer Prevention Research. The annual event is sponsored by the American Association for Cancer Research, whose mission is to prevent and cure cancer through research, education, communication and collaboration.

Prior preclinical studies have shown that flavonoids have beneficial effects against prostate cancer, but few studies have examined the effect of flavonoids on prostate cancer in humans.

Steck and her colleagues used data from 920 African-American men and 977 white men in the North Carolina-Louisiana Prostate Cancer Project who were newly diagnosed with prostate cancer. Participants completed a self-reported dietary history questionnaire to assess flavonoid intake, which was measured using the U.S. Department of Agriculture's 2011 Database for the Flavonoid Content of Selected Foods.

Men with the highest total intake of flavonoids had a 25 percent lower risk for aggressive prostate cancer compared with those men with the lowest flavonoid intake.

"We found that higher total flavonoid intake was associated with reduced odds for aggressive prostate cancer in both African-American and European-American men, but no individual subclass of flavonoids appeared to be protective independently, suggesting that it is important to consume a variety of plant-based foods in the diet, rather than to focus on one specific type of flavonoid or flavonoid-rich food," Steck said.

In addition, the risk for aggressive prostate cancer was even lower in those men younger than 65 and in current smokers with the highest levels of flavonoid intake. Dietary questionnaire results revealed that citrus fruits and juices, such as oranges and grapefruits, tea, grapes, strawberries, onions and cooked greens were the top contributors to total flavonoid intake among the participants. "The results support public health recommendations and guidelines from organizations such as the American Institute for Cancer Research to consume a more plant-based diet," Steck said. "In particular, consuming more flavonoid-rich foods may be beneficial for those people who are at increased risk for cancer, such as smokers."

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The above story is reprinted from materials provided by University of South Carolina, via Newswise.

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Prolonged formula feeding, delay in solid foods was associated with increased risk for pediatric acute lymphoblastic leukemia

ScienceDaily (Oct. 17, 2012) — Results of one study indicate that the risk for developing pediatric acute lymphoblastic leukemia increased the longer a baby was fed formula and the longer solid foods were delayed.

"For every month that a child was fed formula, taking into account other feeding practices, we found that the risk for this type of cancer was higher," said Jeremy Schraw, a graduate student at The University of Texas at Austin, who presented the findings of an epidemiological study at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, held in Anaheim, Calif. Oct. 16-19, 2012. "If a baby is fed only formula, he or she will not be getting any immune factors from the mother, which could be leading to this greater risk."

Schraw and colleagues surveyed 284 controls and 142 children from the Texas Children's Cancer Center and the National Children's Study in Houston, San Antonio and Austin, Texas, who had been diagnosed with acute lymphoblastic leukemia (ALL).

Compared with controls, children diagnosed with ALL started solid foods significantly later, more of their mothers smoked during pregnancy and they had a longer duration of formula feeding.

Researchers found that the risk for developing ALL increased by 16 percent for every month of formula feeding. In addition, for each month the introduction of solid foods was delayed, the risk increased by 14 percent.

"One explanation for this co-risk may be that it's the same effect being picked up twice," said Schraw. "Children being given solid foods later may be receiving formula longer." Future research should address the factors influencing prolonged formula feeding and delay in solid food introduction, according to the researchers.

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The above story is reprinted from materials provided by American Association for Cancer Research (AACR).

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