Pulmonary Carcinoid Tumors and Asbestos Exposure

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Bénédicte Clin1,2,*, Pascal Andujar1,3,4, Issam Abd Al Samad5, Chantal Azpitarte6, FranÇoise Le Pimpec-Barthes7, Marie-Annick Billon-Galland8, Claire Danel9, FranÇoise Galateau-Salle10, Bruno Housset1,3,4, Karinne Legrand-Cattan11, Mireille Matrat1,3,4, Isabelle Monnet4, Marc Riquet7 and Jean-Claude Pairon1,3,4

1Institut National de la Santé et de la Recherche Médicale, U955, Equipe 4, Créteil 94000, France

2Service de Santé au Travail et Pathologie Professionnelle, Centre Hospitalier Universitaire de Caen, Caen 14000, France

3Faculté de Médecine, Université Paris Est, Créteil 94000, France

4Service de Pneumologie et de Pathologie Professionnelle, Centre Hospitalier Intercommunal de Créteil, Créteil 94000, France

5Service d’Anatomie Pathologique, Centre Hospitalier Intercommunal de Créteil, Créteil 94000, France

6Service de Santé au Travail, Société Nationale des Chemins de Fer Français, Paris 75010, France

7Service de Chirurgie Thoracique, Assistance Publique -Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris 75015, France

8Laboratoire d’Etude des Particules Inhalées de la Ville de Paris, Laboratoire d'Etude des Particules Inhalées de la Ville de Paris, Paris 75013, France

9Assistance Publique -Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris 75018, France

10Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Caen, Caen 14000, France

11Service de Santé au Travail, Pôle Santé Travail, Lille 59000, France ?* Author to whom correspondence should be addressed. Tel: +33-2-31-06-54-65; Fax: +33-2-31-06-49-14; e-mail: clin-b{at}chu-caen.fr Received November 10, 2011. Accepted February 14, 2012. Objectives: The hypothesis that asbestos exposure may have more specific associations with particular histological types of lung cancer remains controversial. The aim of this study was to analyze the relationships between asbestos exposure and pulmonary carcinoid tumors.

Methods: A retrospective case–control study was conducted in 28 cases undergoing surgery for pulmonary carcinoid tumors and aged >40 years and in 56 controls with lung cancer of a different histological type, matched for gender and age, from 1994 to 1999, recruited in two hospitals in the region of Paris. Asbestos exposure was assessed via expertise of a standardized occupational questionnaire and mineralogical analysis of lung tissue, with quantification of asbestos bodies (AB). Results: Definite asbestos exposure was identified in 25% of cases and 14% of controls (ns). Cumulative asbestos exposure was significantly higher in cases than in controls (P < 0.05), and results of the quantification of AB tended to be higher in cases than in controls (24 and 9% had >1000 AB per gram dry lung tissue, respectively, P = 0.09). Mean cumulative smoking was lower in cases than in controls (P < 0.05). Conclusions: This study argues in favor of a relationship between asbestos exposure and certain pulmonary carcinoid tumors. © The Author 2012. Published by Oxford University Press on behalf of the British Occupational Hygiene SocietyThis ArticleAnn Occup Hyg (2012) 56 (7): 789-795. doi: 10.1093/annhyg/mes017 First published online: May 4, 2012 PubMed citationArticles by Clin, B.Articles by Andujar, P.Articles by Abd Al Samad, I.Articles by Azpitarte, C.Articles by Le Pimpec-Barthes, F.Articles by Billon-Galland, M. A.Articles by Danel, C.Articles by Galateau-Salle, F.Articles by Housset, B.Articles by Legrand-Cattan, K.Articles by Matrat, M.Articles by Monnet, I.Articles by Riquet, M.Articles by Pairon, J. C.Current Issue
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Posted in: Asbestos, Carcinoid, exposure, Pulmonary, tumors